The Southeast Asia Stigma Reduction QI Learning Network (QIS+D) was launched in 2017 by UCSF-HEALTHQUAL, headquartered in the Institute for Global Health Sciences at the University of California, San Francisco. The Learning Network aims to accelerate the implementation of national- and facility-level HIV-related S+D reduction activities in Cambodia, Lao PDR, Malaysia, Philippines, Thailand, and Vietnam through routine measurement, quality improvement (QI) methods, and peer learning and knowledge exchange.